Genomic and Molecular Medicine Service, Nottingham

The Genomic and Molecular Medicine Service forms part of the integrated ‘East Genomic Laboratory’ (East GLH) service.

The East GLH is responsible for delivery of the genomic tests defined in the new National Genomic Test Directories.  The tests will be either delivered locally or via the East GLH laboratory hub at Addenbrooke’s Hospital, Cambridge. For current turnaround times please see table below.

For further details of the tests delivered locally, select the links below to go to the pages for the Cytogenetics, Molecular Genetics and Molecular Diagnostics sections of the laboratory. 

From 23/01/2025, the UKAS accreditation of the Genomics and Molecular Medicine Service has been suspended for up to six months, please see Letters to users January 2025

East GLH and Nottingham University Hospitals NHS Trust comply with the Data Protection Act and the General Data Protection Regulation (GDPR) and take all possible care to maintain security and confidentiality of personal data.

When required by law or contractual obligation the laboratory will release confidential information. Any request to share patient information is managed and approved in accordance with NUH policies.  

Further information on how patient data is maintained can be found here:

Data Requests & Your Privacy | NUH

 

Page last updated 27/02/2025 Please note that if printed, this information is only valid on the day of printing

Current turnaround times

April 2025

April 2025

Rare Disease Cytogenomics

Clinical Urgency

Example Tests

NHSE Target TAT (Days)

Percentage within Standard

Average TAT (Mean days)

Urgent - Rapid

Microarray / karyotypes for prenatal / urgent postnatal (e.g. neonatal referrals)

14

84%

10.6

Non-urgent - Standard

Standard paediatric or fetal loss microarray

42

54%

41.1

Non-urgent - Standard

Postnatal karyotyping (e.g. fertility or familial microarray follow-up)

42

54%

40.2

 

 

 

 

 

Rare Disease Molecular

Clinical Urgency

Example Tests

NHSE Target TAT (Days)

Percentage within Standard

Average TAT (Mean, Days)

Urgent – Ultra Rapid

QF-PCR for rapid trisomy detection

3

65%

3

Urgent – Ultra Rapid

PCR based prenatal diagnosis

3

50%

5

Urgent – Ultra Rapid

Targeted tests where the result is needed urgently

14

100%

7.9

Urgent – Rapid

Predictive testing

14

85%

11.5

Non-Urgent – Standard

Rare disease single gene screening, known familial variant testing & standard STR based analysis

42

21%

61.8

Non-Urgent – Standard

Rare disease small panel testing (<10 genes)

42

78%

40.2

Non-Urgent – Complex standard

WGS

84

46%

161.9

 

 

 

 

 

Haem-Onc Cytogenomics

Clinical Urgency

Example Tests

NHSE Target TAT (Days)

Percentage within Standard

Average TAT (Mean, Days)

Urgent – Ultra Rapid

Urgent haemato-oncology FISH PML::RARA

3

100%

0.3

Urgent – Ultra Rapid

Urgent haemato-oncology FISH BCR::ABL1

3

100%

1.5

Urgent - Rapid

Urgent haemato-oncology karyotyping/array/FISH

14

82%

12.3

Non-urgent - Standard

Standard haemato-oncology karyotyping/array/FISH

21

70%

16.2

 

 

 

 

 

Haem-Onc Molecular

Clinical Urgency

Example Tests

NHSE Target TAT (Days)

Percentage within Standard

Average TAT (Mean, days)

Urgent – Ultra Rapid

AML(FLT3, NPM1)

3

39%

3.6

Urgent - Rapid

AML NGS Panel

7

58%

8

MPN(JAK2, CALR)

21

92%

14.4

Urgent - Rapid

Chimerism

14

18%

15.4

Diagnostic BCR::ABL1

14

97%

9.1

BCR::ABL1 (Monitoring)

14

53%

8.7

 

 

 

 

 

Solid Cancer   

Clinical Urgency

Example Tests

NHSE Target TAT (Days)

Percentage within Standard

Average TAT (Mean, Days)

Urgent – Rapid

FISH for solid cancers

7

100%

4.5

Urgent – Rapid

BRAF

7

100%

4

Non-urgent Std

NGS-targeted DNA

14

66%

13.1

Non-urgent Std

NGS-targeted RNA

14

68%

13.1

Non-urgent Std

FISH for solid cancers

14

67%

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