If you have symptoms of coronavirus (COVID-19) – a high temperature, a new continuous cough, or a loss of, or change in, your normal sense of smell or taste (anosmia) – the advice is to stay at home for 10 days. All members of this household should remain at home for 14 days.

If you think you have symptoms, please do not attend your hospital appointment until you are advised it is safe to do so. Please contact us to rearrange your appointment, or to re-organise treatment and tests.

Live trials for COVID-19

COVID-19 clinical trials

We are carrying out a number of trials for patients who are being treated at or admitted to NUH for COVID-19.

Our aim is to offer every patient with suspected or confirmed COVID-19 the opportunity to take part in this vital research.

Our research is part of the national and international response to COVID-19. Our expert clinical research teams are helping to find the most effective drugs, vaccines and treatments:

Recovery from COVID-19

  • NoRCoRP - the Nottingham Recovery from COVID-19 Research Platform brings together a number of research projects looking at the impact of COVID-19 and the needs of patients recovering after the infection.
  • PHOSP COVID - involves 20 universities and their partner NHS trusts, as well as charity partners AUK-BLF. It aims to recruit 10,000 people, to understand the longer term effects of COVID-19 for patients after they leave hospital.

Vaccine trials

  • Oxford Vaccine Trial - our experts in experimental medicine, based in our NIHR Nottingham Clinical Research Facility, are supporting the first national trial of a vaccine for COVID-19. Taking place at Cripps Health Centre on the University of Nottingham campus, this trial involves frontline health and social care staff aged over 18 years.
  • NHS COVID-19 Vaccine Registry - you can sign up to take part in future trials now as part of the national volunteer programme to find an effective vaccine.

Tests for COVID-19

  • FALCON - the Facilitating AcceLerated Clinical validation Of novel diagnostics for COVID-19 is a national trial to rapidly assess new diagnostic tests for COVID-19. Nationally the study will assess  approximately 10 new tests. Many of those tests are likely to be point of care tests, which can be done at the patient's bedside and which often return results in as little as five minutes
  • Using Medical Detection dogs to identify people with COVID-19 - from September 2020 researchers at NUH will join a national trial to test whether sniffer dogs can detect COVID-19

Drug and treatment trials

  • RECOVERY - there are no specific treatments for COVID-19. This trial is investigating five different drugs, currently used for other conditions, to see if they have benefits for patients with COVID-19. The Randomised Evaluation of COVid-19 thERapY (RECOVERY) trial will provide doctors and health services with information they need to determine which treatments should be used. Initially for adults, we have now extended this trial at NUH to include newborns, children and young people under the age of 18 years.
  • REMAP-CAP – this study is identifying the most clinically effective interventions for adult patients admitted to an intensive care unit with community-acquired pneumonia and COVID-19.
  • SNG001 - this trial is investigating the use of a formulation of the drug, interferon beta, in adults with COVID-19. In this trial, patients will either receive the drug or a placebo (which does not contain any active drug). The drug will be given to patients using an inhaler.
  • ACCORD-2 - this is a national trial to fast-track the development of new drugs for treating COVID-19. It is a partnership between the NHS, the pharmaceutical industry and specialist research centres including the NIHR Nottingham Clinical Research Facility based at NUH.
  • RECOVERY-RS - this trial is investigating the most effective way to administer oxygen to COVID-19 patients. Methods including CPAP and High Flow Nasal Oxygen (HFNO) are being used, comparing with more commonly used masks and nasal tubes.

Understanding COVID-19 

  • ISARIC - NUH is already part of the International Severe Acute Respiratory and Emerging Infection Consortium (ISARIC) which is working to investigate severe acute respiratory illnesses (SARI). Data from patients at NUH suspected of having, or who are confirmed with, COVID-19 is now being included in this research.
  • PRIEST – this study is investigating the most effective ways of triaging people with suspected respiratory infections in emergency care during a pandemic.
  • GenOMICC – looking into the genetic susceptibility of patients to COVID-19 in critical care. This trial is aiming to find genetic markers which may help researchers and clinicians to identify patients who are at greater risk.
  • PACE - a study investigating the effects of COVID-19 for patients with acute myeloid leukemia (AML).
  • COVID-19-BMT - is a study investigating severe COVID-19 infection in allogeneic stem cell recipients. It involves both adults and children of any age who have received allogeneic stem cell transplantation and who have tested positive for COVID-19. 
  • PREPARE-IBD - a study looking at the impacts of COVID-19 for people living with Inflammatory Bowel Disease to improve the treatment and care for patients in the future
  • PROTECT-ASUS - this study is looking at the treatment and care for patients with acute severe ulcerative colitis during the COVID-19 pandemic
  • DIScOVER - comparing disability in activities of daily living for adults with advanced lung cancer or respiratory disease during the COVID-19 pandemic
  • EXCEED - led by the NIHR Leicester Biomedical Research Centre and the University of Leicester, this study is calling for volunteers to help understand why some people develop more severe COVID-19 than others – particularly those from black and minority ethnic communities.

Trials for women and babies

  • UKOSS - the UK Obstentrics Surveillance System (UKOSS) is collecting data from pregnant women who have a COVID-19 diagnosis to help understand more about how the virus may affect women and infants.
  • PAN-COVID - this study is looking at the impacts of COVID-19 on pregnant women and their babies. 
  • Neonatal complications of COVID-19 - this study is collecting information about newborn babies who have Coronavirus or who are born to mothers who have Coronavirus.

Experiences of COVID-19

  • Psychological impact of COVID-19 - this international study is aiming to better understand how Coronavirus and the restrictions necessary to prevent its spread are impacting on our day to day lifestyle. This study is using an online questionnaire and is open to anyone over the age of 16 years.
  • Communications and COVID-19 - this study is led by the Royal Free London NHS Foundation Trust and is open to healthcare workers to feedback their experiences. 

End of life care

  • COV-Pall - a rapid evaluation of the COVID-19 pandemic response in palliative and end of life care.

New ways of working

  • COVID-NURSE - is evaluating the impact on patient experience of a combination of nursing innovations. NUH is part of a consortium of universities and NHS trusts, working together to build the evidence that will help nursing teams nationally and internationally to adopt best practice for care during a pandemic.



Take part in a trial

Take part in a trial

At NUH we run hundreds of clinical trials every year. We are only able to do this because our patients, carers and families volunteer to take part in and support our research.

Join our research

Our aim is to offer every patient the opportunity to take part in clinical research at our hospitals. You can ask the team caring for you about research taking place now.

In 2019/20 over 14,000 people took part in clinical trials here, enabling us to test new treatments, technology and therapies which will help to improve healthcare for thousands of people.

Live trials

NUH live research trials

Our planned programme of research in 2020 has changed. In response to the pandemic, we have prioritising research to support patients admitted to NUH with COVID-19 or suspected.

Our COVID-19 research is also looking at the longer-term effects for patients who are recovering, but still expriencing symptoms which are impacting on their lives.

You can see some of the trials currently open and looking for people to take part on our Live Trials pages. Please check with your Research Team about how COVID-19 may be impacting on research studies that you are taking part in.

All live research trials

You can also find out about all of the research trials that are currently looking for volunteers here. You can search for a particular disease or condition, or look up all of the trials currently taking place in Nottingham.

Ask your clinical team about research

Please also ask your clinical team about research trials that you may be able to take part in at NUH.

Who can take part in a clinical trial?

It depends on the trial. Some trials (usually Phase 2 or 3 trials) use only people with certain diseases or conditions, or whose family members have certain diseases or conditions. Other trials can use people who are healthy.

Not everyone who wants to be in a trial can be in one. To be in a trial, you need to meet certain conditions. Often, you need to have the disease or problem being studied. Other conditions usually have to do with the health of your heart, liver, kidneys, or other organs. To see if you meet the conditions needed for the research, you might need to answer questions or undergo a medical examination or tests like blood tests.

If you are a patient at NUH, you will usually be asked by the doctors or nurses treating you if you would be willing to take part in current research happening in our hospitals.  You are free to say yes or no, and your treatment and care will not be affected by what you decide.

Learn more about clinical trials

A clinical trial is a research study that uses people to find new ways to improve healthcare. Trials are vital to the development of the quality and effectiveness of the health and social care that patients receive. Clinical trials help to provide the answers to the health problems we have today and ensure that the next generation of patients will receive better care.  Creating this new knowledge relies on current patients and members of the public volunteering to take part.

Clinical trials can:

  • test new treatments to see if they help with certain diseases or conditions better than the current treatments
  • test treatments or lifestyle changes to see if they prevent or lower the chance of getting certain diseases
  • test new ways of finding out if people have certain diseases


Clinical trials that test new treatments, such as medicines, fall into one of three types. The type of trial depends on its goal and how much testing the treatment has already had.

The different types of treatment trials are:

  • phase 1 (I) trials – in Phase 1 trials, researchers check the safety of a new treatment. They learn how the medicine should be given, how often it should be given, what dose is safe, and what the side effects are.
  • phase 2 (II) trials – in Phase 2 trials, researchers give a new treatment to a group of people with a certain disease. They check the treatment's side effects and how well it works to treat the disease.
  • phase 3 (III) trials – in Phase 3 trials, researchers compare a new treatment with the current treatment for a certain disease. They learn if the new treatment helps the disease better, worse, or the same as the current treatment. They also learn if the new treatment has more or fewer side effects than the current treatment.

What are the benefits of taking part in a clinical trial?

People can benefit from taking part in clinical research trials in different ways:

  • Help to advance scientific and clinical knowledge about our health and wellbeing
  • the chance to test a new treatment at an early stage
  • work with research experts who have a great deal of knowledge of the disease and have your progress regularly monitored
  • help people who will have your disease in the future, by supporting the development of new and more effective treatments, therapies or medicines
  • learn about your health and about clinical research in general

Before deciding whether taking part in a clinical research trial is right for you, you should consider all of the information available to you from the research teams. They will explain how the trial will work, any risks or side-effects that you may experience and also the benefits of the treatments being tested. They will also explain any downsides to taking part, for example that the new treatment they are testing could be less effective than the treatment you are already receiving.

Please be aware that:

  • You might not get the new treatment – our research will compare a new treatment with the "usual" treatment for a disease. Other studies compare a new treatment with a "placebo". A placebo is a treatment that looks the same as medicine and is given the same way, but doesn't have any medicine in it. A placebo is used only if doctors aren't sure that the usual treatment helps or if there isn't any good treatment for that disease or condition.
  • In studies that compare two treatments, half of the people get the new treatment, and the other half get the usual treatment or placebo. Neither you nor your researchers can choose which treatment you get. Also, in many cases, you won't know which treatment you got until the trial is over.

If you decide to take part in a trial, you will need to give your written consent.


Make sure you're happy with the trial and have been given all the information you want before you give your consent (permission). This may mean taking some time to think about it and talk it over with family or friends, unless a decision is needed urgently because of your medical condition.

If you decide to take part, you'll be asked to sign a form to say you're agreeing to take part in a trial and have understood what it involves. This is called giving your informed consent. 

For people under the age of 18, a parent or guardian has to give informed consent.

Using your data in our research

Using your data

Protecting your information

Our research is only possible because of the patients, families and carers who agree to use their data as part of our research. At every stage of our research, we are committed to protecting your privacy, confidentiality and dignity. That includes using your data responsibly.

Our researchers are specially trained, qualified and authorised to work with your data. We handle and store data in the most secure ways possible. We will only use your data with the proper approvals, following independent review of how we plan to use the data for research and with full security of your data in place. We will only use your data to improve health and care.

The video above summarises how the NHS uses data to save lives and improve treatment and care; we are grateful to the Understanding Patient Data initiative for these resources. You will find more information and resources on the Understanding Patient Data website.

Our commitment to you

At NUH we make the following commitments about the data we keep about you and the way that we protect it. We will:

  • Keep the right information to provide services and fulfil our legal responsibilities to you
  • Keep your records safe, secure and accurate
  • Only keep your information as long as necessary
  • Collect, store and use the information you provide to the data protection standards and the laws that govern data protection
  • Comply with the NUH Privacy Policy and the General Data Protection Regulation (GDPR), which requires that the way we manage your personal data is fair, lawful and transparent.

Sharing data for research

By bringing together small amounts of data from many thousands of patients, health researchers and scientists can look for patterns across the population. This type of data analysis can be used to help:

  • understand more about disease risks and causes
  • improve diagnosis
  • develop new treatments and prevent disease
  • plan NHS services
  • improve patient safety

How the NHS uses data for research in the UK

The Health Research Authority (HRA) is the national body which protects and promotes the interests of patients and the public in health and social care research. It provides information about how data is used for research in the UK. You can find details of this information on the HRA website.

Choose how your data is used

You can choose if your health data is used for clinical research or for NHS and social care planning. Find out about how health data is used nationally and about your choices on the NHS website.

Data Opt Out

You can choose how your data is used by the NHS for planning and clinical research.

Find out more about the Data Opt Out on the NHS Digital website.

Our partners

We are working with our partners in the University of Nottingham to develop the skills and capabilities to analyse extremely large amounts of data for research.

We are also working nationally as part of information collaborations and new developments in research data to improve healthcare across the country.  

Your safety

Our experts check all trials – before and during them – to make sure that they are safe. Our research is also accredited by the relevant national regulatory or sponsoring organisation to ensure that we consistently meet all of the standards required to carry out clinical research in the UK. If there are signs that the treatment in a trial could be unsafe, the research team or the regulators will stop the trial. 

During the trial, you will need to follow all of the instructions about visits, tests, and treatments. This may be over a period of days, weeks or months. If you experience any problems, issues or side-effects, you should contact your research doctor or nurse.

You may decide to stop taking part in a trial if your condition is getting worse or if you feel the treatment isn't helping you. You can also choose to leave at any point without giving a reason and without it affecting the care you receive.