Hereditary ovarian cancer

The resources below have been developed to support the implementation of mainstream genetic testing for hereditary ovarian cancer across cancer services in Nottinghamshire, Lincolnshire, and Derbyshire. This includes the R207 panel for inherited ovarian cancer (without breast cancer), which now comprises the following genes:

BRCA1, BRCA2, PALB2, MLH1, MSH2, MSH6, BRIP1, RAD51C, RAD51D

This approach is referred to as Mainstreaming Cancer Genetics (MCG) and enables genetic testing to be offered directly through cancer services.

These materials have been tailored for use within our Trust and the district hospitals we support. They are suitable for completion by any specialist nurse or clinician involved in the care of patients with ovarian cancer.

Please note: Until 1 January 2023, only the R207 Lite panel was available in our region, which did not include RAD51C, RAD51D, or BRIP1.

If you have any questions or require further information, please contact: nuhnt.clinicalgenetics@nhs.net

Steps for training

Steps for training

1. Email nuhnt.clinicalgenetics@nhs.net to arrange a time for face to face or virtual training.

2. Read the frequently asked questions before the face to face training:    MCG-FAQ1 V4.doc [doc] 123KB

Useful documents

• Frequently asked questions booklet:   MCG-FAQ1 V4.doc [doc] 123KB

• Protocol for the Nottingham gynae-oncology appointment:  MCG P2 V7 Ovarian Notts.pptx [pptx] 85KB

• Family history questionnaire: FHQ.xls [xls] 37KB

• Record of discussion (consent) form for patients with ovarian cancer:  MCG-OVARIAN ROD FORM 05.05.22.docx [docx] 35KB

• Blood form- Test request form East_GLH_Rare_Disease_Test_Order_Form

UK Cancer genetics group guidelines for BRCA1/2, PALB2, BRIP1, RAD51C/RAD51D and  Lynch syndrome can be found at the UKCGG website (www.UKCGG.org) here UKCGG leaflets and guidelines - Cancer Genetics Group

Information sheets for patients

•Information about R207 Ovarian panel testing:  MCG IS6-R207- v3- Pt info ovarian cancer.doc [doc] 116KB

•A normal result:  MCG-IS2-V5-Pt-info-normal-result-all genes.doc [doc] 62KB

•An unclassified variant:   MCG-IS4-v4-Pt-info-VUS-all genes.docx [docx] 97KB

•A positive BRCA1/2 result:  MCG IS3-v4-BRCA positive.doc [doc] 194KB

•A positive PALB2 result:  MCG IS5-v4 Pt info-PALB2 positive.doc [doc] 154KB

•A positive Lynch (MLH1, MSH2, MSH6) result:  MCG IS7-v1 Pt info-Lynch positive.doc [doc] 195KB 

•A positive BRIP1 result:  MCG IS12-v1 Pt info-BRIP1.doc [doc] 154KB

•A positive RAD51C/D result:  MCG IS11-v1 Pt info-RAD51C-D.doc [doc] 154KB