Inherited Pancreatic cancer
Mainstream Genetic Testing for Inherited Pancreatic Cancer
The resources below have been developed to support the implementation of mainstream genetic testing for inherited Pancreatic cancer across cancer services in Nottinghamshire, Lincolnshire, and Derbyshire.
The R367 Inherited pancreatic cancer genomic panel test currently comprises the following genes:
- ATM
- BRCA1
- BRCA2
- CDKN2A
- PALB2
- STK11
This approach is referred to as Mainstreaming Cancer Genetics (MCG) and enables genetic testing to be offered directly through cancer services.
Testing can currently be offered by Clinical Genetics, Gastroenterology and Oncology to patients who meet the current National Genomic Test Directory eligibility criteria, including:
- Pancreatic cancer age <60, OR
- Pancreatic cancer age <70, AND
- Breast cancer age <60, melanoma age <60, OR ovarian cancer, OR
- One first / second degree relative with pancreatic cancer age <60, OR
- Two or more first / second degree relatives with any of:
- breast cancer age <60,
- melanoma age <60,
- OR ovarian cancer (any age)
- OR two or more with pancreatic cancer (any age)
If your department is not currently offering mainstream genetic testing for inherited Pancreatic cancer and is located within the Nottinghamshire, Lincolnshire, and Derbyshire area, please contact the Clinical Genetics team. We can provide advice and support to help establish a local testing pathway, including training and educational resources for clinicians and specialist nurses.
Current eligibility criteria can be found in the https://www.england.nhs.uk/publication/national-genomic-test-directories/, and information on the current gene panel is available through PanelApp .
Contact
If you have any questions, require further information, or would like support with implementing mainstream testing, please contact: