Our first COVID-19 trials
Our earliest trials reporting results
The folowing COVID-19 studies were amongst the first to return results which helped to chnage the treatment options for people with COVID-19.
- COG-UK HOCI - this study investigated how integrating rapid, real-time COVID-19 genomic sequencing can impact decision-making by infection control teams to prevent the spread of the SARS-CoV-2 virus in NHS hospitals.
- Com-Cov study - the purpose of this trial was to see how well people’s immune systems respond when their first dose is one type of vaccine, and their second is another. It will also see how good the response is when the second dose is separated from the first dose by different periods of time.
- Communications and COVID-19 - this study was led by the Royal Free London NHS Foundation Trust and gathered feedback from healthcare workers on their experiences.
- COVID-NURSE - evaluated the impact on patient experience of a combination of nursing innovations. NUH was part of a consortium of universities and NHS trusts, working together to build the evidence that will help nursing teams nationally and internationally to adopt best practice for care during a pandemic.
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Medical Detection Dogs - People with COVID-19 do not always have symptoms (asymptomatic). This study, led by the London School of Hygiene and Tropical Medicine, Durham University and the charity Medical Detection Dogs, investigated whether dogs may be able to identify asymptomatic patients, as well as those who have mild symptoms (symptoms not requiring treatment, hospital stay or limiting normal activities).
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Oxford Vaccine Trial - our experts in experimental medicine, based in our NIHR Nottingham Clinical Research Facility, supported the first national trial of a vaccine for COVID-19. Taking place at Cripps Health Centre on the University of Nottingham campus, this trial involved frontline health and social care staff aged over 18 years. Over 520 patients took part in this trial in Nottingham and will continue to be followed-up by the research team.
- PACE - a study investigating the effects of COVID-19 for patients with acute myeloid leukemia (AML).
- PRIEST – this study looked at the most effective ways of triaging people with suspected respiratory infections in emergency care during a pandemic.
- PREPARE-IBD - a study looking at the impacts of COVID-19 for people living with Inflammatory Bowel Disease to improve the treatment and care for patients in the future
- PROTECT-ASUS - this study looked at the treatment and care for patients with acute severe ulcerative colitis during the COVID-19 pandemic
- Psychological impact of COVID-19 - this international study aimed to better understand how Coronavirus and the restrictions necessary to prevent its spread impacted on our day to day lifestyle. It used an online questionnaire and was open to anyone over the age of 16 years.
- SIREN - this study led to greater understanding of whether prior infection with SARS-CoV2 (the virus that causes COVID-19) protects against future infection with the same virus.
- SNG001 - this trial investigated the use of a formulation of the drug, interferon beta, in adults with COVID-19. In this trial, patients either received the drug or a placebo (which does not contain any active drug). The drug will be given to patients using an inhaler.
- What's the Story - this study involved donation of a blood sample from people aged from birth to 24 years of age to look at their antibody levels against important infectious diseases. The study was initially set up to look at Group C meningococcus (MenC) and diphtheria and was then adapted to include COVID-19.