There is an active programme of collaborative paediatric respiratory research in Nottingham.
Here is a description of ongoing respiratory studies:
- CEFIT-CF: Performing careful measurement of kidney function in patients with CF to look for any drug related or CF related effects
- CRITIC: Randomised pharmacokinetic comparison of once daily tobramycin administration in morning vs. evening
- MRC biomarkers study: Study which looks for sensitive indicators of pseudomonas infection in CF patients
- TORPEDO: Multicentre randomised controlled trial of intravenous vs. oral eradication treatment for pseudomonas in CF
- WAIT: Wheeze and intermittent treatment
- PASS: Pharmacogenetics of adrenal suppression with inhaled steroids.
We also take part in clinical trials run by commercial pharmaceutical companies, as well as undertaking Cochrane systematic reviews and epidemiological studies. We have a programme of laboratory based research looking at ways of reducing pseudomonas virulence and increasing antibiotic sensitivity. We support studies undertaken through Medicines for Children Research Network East (MCRN-East), part of the National Institute for Health Research (NIHR) Clinical Research Network.
As a team we are actively involved with various educational meetings such as BPRS annually, East Midlands Mid Trent CF meeting twice a year, acath training days four times a year, and CF study day for school staff annually.