How accurate is the Vanadis NIPT test for Trisomy Screening?
|
Condition |
Sensitivity (95% CI) |
Specificity (95% CI)
|
Positive Predictive Value (PPV) |
Negative Predictive Value (NPV) |
|
T21a |
>99 % (95.5-100%) |
>99% (98.3-99.8%)
|
98.8% |
>99% |
|
T18b |
91.7% (77.5-98.2%) |
>99% (99.2-99.9%)
|
91.7% |
>99% |
|
T13b |
>99% (69.2-100%)
|
>99% (99.5-100%)
|
90.9% |
>99% |
a = based 747 patient samples
b = based on 1035 patient samples
95% Confidence Interval (CI) – In 95% of samples tested the sensitivity or specificity of the test will be within the reported range
Sensitivity - The ability of the Vanadis NIPT test to identify the condition in pregnancies affected by the condition
Specificity - The ability of the Vanadis NIPT test to correctly identify pregnancies not affected by the condition
PPV - The number of truly positive/affected pregnancies that were reported as positive by the Vanadis NIPT test
NPV - The number of truly negative/unaffected pregnancies that were reported as negative by the Vanadis NIPT test